SLN - Team Wieser
Dr. Stefan Wieser
- Activities:
Our team works at the interface of physics and biology. We are developing live cell super-resolution imaging techniques for 3D imaging of whole cell dynamics. We mainly focus on immune cells with the aim to study the intrinsic coupling between leucocyte migration, cell polarization and antigen presentation. To gain a mechanistic understanding of these processes we apply advanced imaging techniques - with focus on SIM - and data analysis tools that allow for integrating molecular dynamics with large-scale cell behavior. The ultimate goal is to develop mathematical models with predictive capacity from the molecular scale to global cell behavior and immune cell function.
- Collaborations:
- Lattice Light Sheet Microscopy
- High NA-TIRF Structured Illumination Microscopy
- 2D/3D live cell single molecule imaging
- Advanced biomimetic interfaces
- Quantitative Data Analysis Tools and Monte Carlo Simulations
- Immune cell migration
- Temperature control of immune cell responses
- Research Topics:
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SLN - Team Wieser
Dr. Stefan Wieser
- Team Leader
- Dr. Stefan Wieser
- Research Engineers
- Dr. Boris Karamata
- Visiting PhD Students
- Loïc Reymond
- Former Group Members
- Johannes Ziegler, Research engineer
SLN - Team Wieser
Dr. Stefan Wieser
- Regular Papers
- The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior Science 370, eaba2644 (2020) Highlighted in Science
- Modulation-enhanced localization microscopy (meLM) J. Phys. Photonics [Online DOI: 10.1088/2515-7647/ab9eac] (2020)
- Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity eLife 9, e55111 (2020)
- A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs Sci. Adv. 6, eaaz1588 (2020)
- Hypolipidemic effects of herbal extracts by reduction of adipocyte differentiation, intracellular neutral lipid content, lipolysis, fatty acid exchange and lipid droplet motility Sci. Rep. 9, 10492 (2019)
- SIMPLE: Structured illumination based point localization estimator with enhanced precision Opt. Express 27, 24578 (2019)
- Neuronal stretch reception – Making sense of the mechanosense Experimental Cell Research 378, 104-112 (2019)
- Talks
- How do cells sense physical forces? Cellular mechanosensing and motility in biomimetic 3D environments Joint 12th EBSA European Biophysics Congress / 10th IUPAP International Conference on Biological Physics (ICBP), Madrid, Spain, July 2019
- Mechanosensitive actomyosin network dynamics and migration plasticity in 3D environments Joint 12th EBSA European Biophysics Congress / 10th IUPAP International Conference on Biological Physics (ICBP), Madrid, Spain, July 2019
- SIMPLE: Structured illumination localization microscopy Joint 12th EBSA European Biophysics Congress / 10th IUPAP International Conference on Biological Physics (ICBP), Madrid, Spain, July 2019
SLN - Team Wieser
Dr. Stefan Wieser
- 2020-10-16 When feeling the pinch, nuclei instigate cells to escape crowded spaces Scientists from CRG, ICFO, FH OÖ and UPF report on this new finding in a study published in the journal Science.
- 2020-04-24 Congratulations to New ICFO PhD graduate Dr. Pablo Gómez García graduated with a thesis entitled “Development and Application of Localization-Based Microscopy Methods to Study the Structure and Dynamics of Chromatin through the Process of Cellular Differentiation”
- 2016-11-22 New Team Leader Dr. Stefan Wieser joins ICFO as a PI Staff Scientist within the SLN Program
