Neurophotonics and Mechanical Systems Biology
Prof. Dr. Michael Krieg
- Activities:
Our main research goal is to understand the importance of cell mechanical properties for health and disease on the molecular and systems level. Mechanical forces are ubiquitous signals that provide information about our environments and our own body during touch and as we walk, breathe, and fall in love. Although failures to sense and cope with mechanical forces are linked to human diseases including peripheral neuropathies and neurodegenerative disorders, little is known about the connections between biomechanics and disease. One reason for this gap is the technical challenge of detecting forces and the deformations resulting from them within a living cell or organism. To fill this gap and advance our understanding, we develop and deploy new optogenetic tools (FRET, synthetic biology and genetic code expansion) to measure piconewton force and their consequences inside cells. From these data and informed by theoretical predictions, we derive insight and mechanistic understanding of how changes in protein and cell mechanics contribute to pathological transformations in mechanosensation and protection.
Due to the wealth of genetic tools available for it, we use the small round worm, Caenorhabditis elegans, with its compact nervous system consisting of only 302 neurons, its short lifespan and simple body plan, as a model. We exploit microfluidic and nanotechnological tools to apply precise forces to single cells or animals. Simultaneously we visualize mechanical forces and their consequences using optogenetic stress sensors and state-of-the-art microscopy.
We are hiring: PhD-students in Neuronal Cell Biology. Please contact This email address is being protected from spambots. You need JavaScript enabled to view it. for further information.
- Position(s) Available:
- Research Engineer position in Parallel Computing for Systems Neuroscience
- Research Engineer position in Molecular Biology and Screening specialist
- Post-doctoral position in optogenetics and cellular neuroscience
- Research Topics:
- Towards A Unifying Principle Of Mechanosensation
- Mechanical Stress In Neurodegeneration
- Engineering A Prosthetic Cellular Communication System
- Links:
- Group homepage
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.
Neurophotonics and Mechanical Systems Biology
Prof. Dr. Michael Krieg
- Group Leader
- Prof. Dr. Michael Krieg
- Postdoctoral Researchers
- Ravi Das
- Montserrat Porta
- PhD Students
- Lynn Lin
- Martina Rita Mocera
- Undergrad & Postgrad Students
- Joaquin Alberto Ascencio Rodríguez
- Sara González Bolívar
- Iris Ruider
- ICFO Summer Fellows
- Albert Edo Pérez
- Former Group Members
- Tihomir Georgiev, Postdoctoral researcher
Neurophotonics and Mechanical Systems Biology
Prof. Dr. Michael Krieg
- Regular Papers
- Genetic defects in ß-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling eLife 6, (2017)
- Pneumatic stimulation of C. elegans mechanoreceptor neurons in a microfluidic trap Lab Chip 17, 1116-1127 (2017)
Neurophotonics and Mechanical Systems Biology
Prof. Dr. Michael Krieg
- 2017-05-17 NEW GROUP LEADER Dr. Michael Krieg joins ICFO to start a new group focusing on Neurophotonics and Mechanical Systems Biology
