28 September 2012 ICFO in Nano Today

Different possibilities for combining AFM and NSOM to measure and probe complex biochemical and mechanical properties in living cells

Prof. Maria Garcia-Parajo reports on recent progress in cell surface nanoscopy. In this paper, Prof. Maria Garcia-Parajo discusses recent advances made possible by surface nanoscopy. In the past years, breakthrough in this rapidly advancing area are allowing researchers to understand the specific nanometer-scale organization and distribution of the surface machinery of living cells and the role these molecular properties play in the spatiotemporal control of different cellular processes. Near-field scanning optical microscopy (NSOM) and atomic force microscopy (AFM) have been central to these new insights.